IL-1β, BK, and TGF-β1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA
作者： H. El-Haroun , D. L. Clarke , K. Deacon , D. Bradbury , A. Clayton
DOI: 10.1152/AJPLUNG.00044.2006
关键词: Bradykinin 、 Prostacyclin 、 Mitogen-activated protein kinase kinase 、 MAP kinase kinase kinase 、 Prostacyclin receptor 、 Protein kinase A 、 Internal medicine 、 Endocrinology 、 Transforming growth factor 、 Interleukin 、 Biology
摘要: We have previously shown that interleukin (IL)-1β, transforming growth factor (TGF)-β1, or bradykinin (BK) impair cAMP generation in response to prostacyclin analogs human pulmonary artery smoot...
sci-hub.se 参考文章(48)
J Inglese, N.J. Freedman, W.J. Koch, R.J. Lefkowitz, Structure and mechanism of the G protein-coupled receptor kinases. Journal of Biological Chemistry. ,vol. 268, pp. 23735- 23738 ,(1993) , 10.1016/S0021-9258(20)80439-6
Padmini Komalavilas, Shyamal Mehta, Christopher J. Wingard, Daniel T. Dransfield, Jyoti Bhalla, Julie E. Woodrum, Jason R. Molinaro, Colleen M. Brophy, PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways. Journal of Applied Physiology. ,vol. 91, pp. 1819- 1827 ,(2001) , 10.1152/JAPPL.2001.91.4.1819
Judith C W Mak, Takeshi Hisada, Michael Salmon, Peter J Barnes, K Fan Chung, Glucocorticoids reverse IL-1β-induced impairment of β-adrenoceptor-mediated relaxation and up-regulation of G-protein-coupled receptor kinases British Journal of Pharmacology. ,vol. 135, pp. 987- 996 ,(2002) , 10.1038/SJ.BJP.0704545
Gensho Iwami, Jun-ichi Kawabe, Toshiaki Ebina, Paul J. Cannon, Charles J. Homcy, Yoshihiro Ishikawa, Regulation of Adenylyl Cyclase by Protein Kinase A Journal of Biological Chemistry. ,vol. 270, pp. 12481- 12484 ,(1995) , 10.1074/JBC.270.21.12481
Robert J. Lefkowitz, William P. Hausdorff, Marc G. Caron, Role of phosphorylation in desensitization of the β-adrenoceptor Trends in Pharmacological Sciences. ,vol. 11, pp. 190- 194 ,(1990) , 10.1016/0165-6147(90)90113-M
Bipin G. Nair, Yiming Yu, Hani M. Rashed, Hui Sun, Tarun B. Patel, TRANSFORMING GROWTH FACTOR-BETA 1 MODULATES ADENYLYL CYCLASE SIGNALING ELEMENTS AND EPIDERMAL GROWTH FACTOR SIGNALING IN CARDIOMYOCYTES Journal of Cellular Physiology. ,vol. 164, pp. 232- 239 ,(1995) , 10.1002/JCP.1041640203
Marius M. Hoeper, Michael Schwarze, Stefan Ehlerding, Angelika Adler-Schuermeyer, Edda Spiekerkoetter, Jost Niedermeyer, Michael Hamm, Helmut Fabel, Long-Term Treatment of Primary Pulmonary Hypertension with Aerosolized Iloprost, a Prostacyclin Analogue The New England Journal of Medicine. ,vol. 342, pp. 1866- 1870 ,(2000) , 10.1056/NEJM200006223422503
Félicien Karege, Michèle Schwald, Carmen Lambercy, Jean-Jacques Murama, Mbaye Cisse, Alain Malafosse, A non-radioactive assay for the cAMP-dependent protein kinase activity in rat brain homogenates and age-related changes in hippocampus and cortex. Brain Research. ,vol. 903, pp. 86- 93 ,(2001) , 10.1016/S0006-8993(01)02409-X
Yong M. Zhu, Dawn A. Bradbury, Linhua Pang, Alan J. Knox, Transcriptional Regulation of Interleukin (IL)-8 by Bradykinin in Human Airway Smooth Muscle Cells Involves Prostanoid-dependent Activation of AP-1 and Nuclear Factor (NF)-IL-6 and Prostanoid-independent Activation of NF-κB Journal of Biological Chemistry. ,vol. 278, pp. 29366- 29375 ,(2003) , 10.1074/JBC.M301785200
Matthew H. Kim, Devendra K. Agrawal, Effect of interleukin-1β and tumor necrosis factor-α on the expression of G-proteins in CD4+ T-cells of atopic asthmatic subjects Journal of Asthma. ,vol. 39, pp. 441- 448 ,(2002) , 10.1081/JAS-120004037