Receptor-Mediated Signal Transduction and Cell Signaling

摘要: The maintenance of low resistance, pressure, and tone in the pulmonary circulation is dependent on interaction circulating locally produced vasomodulatory regulators; many such vasoactive mediators act via receptor-mediated signaling pathways. Many types receptors that regulate vascular are expressed plasma membrane cells, although vasomotor activity also influenced by intracellular receptors, as calcium-release transcription (e.g., steroid hormone receptors). vasculature expresses a wide variety receptor classes subtypes facilitate cells with their extracellular environment (hormones, neurotransmitters, other factors milieu play key roles modifying blood flow under both physiological patho-physiological conditions). One can identify assessing binding radioligands, molecular cloning expression studies, antisense approaches, and/or conducting studies transgenic or knockout animals. Receptor-mediated changes development disease, highly species specific, cell-type often depends an intact endothelium. Moreover, accessibility for neurotransmitters hormones from makes them excellent drug targets. major G-protein-coupled ligand-gated ion channels, protein kinases [receptor tyrosine kinase serine/threonine receptors]. This chapter provides overview cell-surface highlights whose activation regulates development, tone, permeability.