The Role of Upregulated DDX11 as A Potential Prognostic and Diagnostic Biomarker in Lung Adenocarcinoma
作者： Jianhao Li , Liwen Liu , Xin Liu , Penglin Xu , Qiuyue Hu
DOI: 10.7150/JCA.33457
关键词: Receiver operating characteristic 、 Cell cycle 、 Cancer research 、 Clinical significance 、 Tissue microarray 、 Lung cancer 、 Cyclin-dependent kinase 6 、 Adenocarcinoma 、 Proportional hazards model 、 Medicine 、 Oncology
摘要: Background: Lung adenocarcinoma (ADC) is the main cause of cancer-related mortality in lung cancer patients. DEAD/DEAH box helicase 11 (DDX11) was previously shown to be dysregulated and exert oncogenic activity cancer. However, diagnostic value clinical significance DDX11 ADC remain unknown. Methods: A total 513 59 normal tissue samples were obtained from The Cancer Genome Atlas (TCGA) database, mRNA expression level evaluated. Additionally, a meta-analysis 7 cohorts Gene Expression Omnibus (GEO) database conducted validate pattern. Moreover, receiver operating characteristic (ROC) curve analysis used identify power ADC. microarray (TMA) comprising 86 specimens their adjacent applied indicate protein status. In addition, Kaplan-Meier Cox regression analyses prognostic Finally, molecular mechanism action predicted by gene set enrichment (GSEA). Results: upregulated tissues associated with worse overall survival (OS). ROC curves showed high values for diagnosis. has remarkable correlations DNA replication cell cycle G1-S phase pathway. Consistently, it genes, such as CCNA2, CCNB1, CCNC, CCND1, CCNE1, CDK2, CDK4 CDK6. CCNE1 CDK6 patients OS progression-free (PFS). Conclusion: significantly poor prognosis This might serve potential novel biomarker
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