Analysis of tumor markers in the cytological fluid obtained from computed tomography-guided needle aspiration biopsy for the diagnosis of non-small cell lung cancer.

摘要: Purpose The aim of this study was to prospectively assess whether analysis the tumor markers cytokeratin 19 fragments (CYFRA 21-1), carcinoembryonic antigen (CEA), and squamous cell carcinoma (SCC) in cytological fluid can improve performance computed tomography (CT)-guided needle aspiration biopsy (NAB) diagnosis non-small lung cancer (NSCLC). Methods A total 100 patients (men:women = 41:59, mean age: 63 years) with suspected malignant pulmonary lesions were enrolled for CT-guided NAB procedures. Levels CYFRA 21-1, CEA, SCC measured by immunoradiometric assays. cutoff value selected on basis best accuracy through receiver operating characteristic curves. sensitivity areas under curve (AUC) alone compared those combined SCC). Results Among patients, 71 (71%) had NSCLC 29 (29%) benign lesions. sensitivity, specificity, diagnosing 85.7%, 100%, 89%, respectively, alone. increased significantly a marker (100% 92.9% 94.2% SCC; p 0.001, 0.025, 0.014, respectively). AUC 21-1 larger than (p 0.001). Conclusion Evaluation diagnostic NSCLC. Of these markers, is most useful marker.