Pulmonary Hypertension in Critically Ill Patients

作者: Hooman D. Poor , Corey E. Ventetuolo , Todd M. Bull

DOI: 10.1007/978-1-4939-2636-7_18

关键词: HemodynamicsPathophysiologyCritically illPulmonary hypertensionMedicineIn patientMortality rateInternal medicineIntensive care unitCardiologyPathogenesis

摘要: Pulmonary hypertension (PH) in critically ill patients requiring the intensive care unit (ICU) is a complex and challenging disorder. Whether elevations of pulmonary arterial pressures are acute or preexisting, significant PH setting illness can lead to rapid deterioration right ventricular (RV) function, precipitating hemodynamic collapse death. Outcomes with who require ICU quite poor. In underlying (PAH) inoperable chronic thromboembolic (CTEPH) admitted ICU, mortality rates between 30 41 % have been reported. Given their fragile status, understanding pathogenesis RV failure secondary critical for rescue successful treatment these patients. this chapter, we will discuss pathophysiology management ICU.

参考文章(199)
Anna R. Hemnes, Sean P. Gaine, Charles M. Wiener, Poor outcomes associated with drainage of pericardial effusions in patients with pulmonary arterial hypertension. Southern Medical Journal. ,vol. 101, pp. 490- 494 ,(2008) , 10.1097/SMJ.0B013E31816C0169
P. Forrest, Anaesthesia and right ventricular failure. Anaesthesia and Intensive Care. ,vol. 37, pp. 370- 385 ,(2009) , 10.1177/0310057X0903700314
R. J. Damiano, P. La Follette, J. L. Cox, J. E. Lowe, W. P. Santamore, Significant left ventricular contribution to right ventricular systolic function. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 261, ,(1991) , 10.1152/AJPHEART.1991.261.5.H1514
Armin Sablotzki, Wolfgang Starzmann, Robert Scheubel, Stefan Grond, Elke G. Czeslick, Selective pulmonary vasodilation with inhaled aerosolized milrinone in heart transplant candidates Canadian Journal of Anaesthesia-journal Canadien D Anesthesie. ,vol. 52, pp. 1076- 1082 ,(2005) , 10.1007/BF03021608
Vedat Ozkul, Abdullah Kemal Tuygun, Pelin Karaca, Nurgul Yurtseven, Serdar Cimen, Gunseli Uysal, Adnan Yuksek, Sevim Canik, A comparison of the acute hemodynamic effects of inhaled nitroglycerin and iloprost in patients with pulmonary hypertension undergoing mitral valve surgery. Annals of Thoracic and Cardiovascular Surgery. ,vol. 12, pp. 319- 323 ,(2006)
Jean-Luc Vachiery, Sandrine Huez, Hunter Gillies, Gary Layton, Naoto Hayashi, Xiang Gao, Robert Naeije, Safety, tolerability and pharmacokinetics of an intravenous bolus of sildenafil in patients with pulmonary arterial hypertension British Journal of Clinical Pharmacology. ,vol. 71, pp. 289- 292 ,(2011) , 10.1111/J.1365-2125.2010.03831.X
K. M. Olsson, A. Simon, M. Strueber, J. Hadem, O. Wiesner, J. Gottlieb, T. Fuehner, S. Fischer, G. Warnecke, C. Kühn, A. Haverich, T. Welte, M. M. Hoeper, Extracorporeal membrane oxygenation in nonintubated patients as bridge to lung transplantation. American Journal of Transplantation. ,vol. 10, pp. 2173- 2178 ,(2010) , 10.1111/J.1600-6143.2010.03192.X
W. M. Zapol, L. M. Reid, J. F. Tomashefski, C. Boggis, P. Davies, R. Greene, The pulmonary vascular lesions of the adult respiratory distress syndrome. American Journal of Pathology. ,vol. 112, pp. 112- 126 ,(1983)
GERALD SIMONNEAU, ROBYN J. BARST, NAZZARENO GALIE, ROBERT NAEIJE, STUART RICH, ROBERT C. BOURGE, ANNE KEOGH, RONALD OUDIZ, ADAANI FROST, SHELMER D. BLACKBURN, JAMES W. CROW, LEWIS J. RUBIN, Continuous subcutaneous infusion of treprostinil, a prostacyclin analogue, in patients with pulmonary arterial hypertension: a double-blind, randomized, placebo-controlled trial. American Journal of Respiratory and Critical Care Medicine. ,vol. 165, pp. 800- 804 ,(2002) , 10.1164/AJRCCM.165.6.2106079