The landscape of uniquely shared archaic alleles in present-day human populations
作者： Fernando Racimo , Davide Marnetto , Emilia Huerta-Sanchez
DOI: 10.1101/045237
关键词: Allele frequency 、 Allele 、 Biology 、 1000 Genomes Project 、 Selection (genetic algorithm) 、 Haplotype 、 Introgression 、 Evolutionary biology 、 Adaptation 、 Candidate gene
摘要: Comparisons of DNA from archaic and modern humans show that these groups interbred, in some cases received an evolutionary advantage doing so. This process - adaptive introgression may lead to a faster rate adaptation than is predicted models with mutation selection alone. Within the last couple years, series studies have identified regions genome are likely examples introgression. In many cases, once region was ascertained as being introgressed, commonly used statistics based on both haplotype well allele frequency information were employed test for positive selection. Introgression by itself, however, changes structure distribution frequencies, thus confounding traditional tests detecting Therefore, patterns generated alone false inferences Here we explore involving investigate behavior various under particular, find number allelic frequencies sites uniquely shared between specific present-day populations particularly useful We then examine 1000 Genomes dataset identify subject discuss most promising candidate genes located regions.
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