Serum uric acid and leptin levels in metabolic syndrome: a quandary over the role of uric acid
作者： Jen-Der Lin , Wen-Ko Chiou , Hung-Yu Chang , Feng-Hsuan Liu , Hsiao-Fen Weng
DOI: 10.1016/J.METABOL.2007.01.006
关键词: Endocrinology 、 Metabolic syndrome 、 Leptin 、 Insulin resistance 、 Diabetes mellitus 、 Internal medicine 、 Obesity 、 Hyperuricemia 、 Waist–hip ratio 、 Uric acid 、 Medicine
摘要: This study investigates the impact of uric acid (UA) on risk factors associated with metabolic syndrome. In addition, this explores relationship between UA and insulin resistance serum leptin levels in A total 470 subjects (252 women 218 men) were recruited from Department Health Management at Chang Gung Medical Center (Linkou, Taiwan). Metabolic syndrome was defined using a modified Adult Treatment Panel III (ATP III) definition. The formula for homeostasis model assessment (HOMA-IR) is as follows: fasting (microU/mL) x plasma glucose (mmol/L)/22.5. Diabetes mellitus diagnosed 45 (9.6%); 82 (17.4%) had hypertension. Hyperuricemia 144 (30.6%). Of these subjects, 115 (63 females 52 males) (24.5%) having Patients hyperuricemia increased body mass index, waist-to-hip ratio, triglyceride (Tg) level. also lower high-density lipoprotein greater Hormone assays showed an elevation leptin, immunoreactive (IRI), HOMA-IR group. Uric appeared to be better correlated Tg, blood pressure (both systolic diastolic), obesity, insulin, HOMA-IR. did not correlate or levels. Tg/high-density ratio statistically significant difference 3.8 cutoff value. Otherwise, there no conclusion, significantly related except glucose. Waist-to-hip different without
elsevier.com
sci-hub.se 参考文章(32)
J.D. Lin, W.K. Chiou, H.F. Weng, J.T. Fang, T.H. Liu, Application of three-dimensional body scanner: observation of prevalence of metabolic syndrome. Clinical Nutrition. ,vol. 23, pp. 1313- 1323 ,(2004) , 10.1016/J.CLNU.2004.04.005
S D Hsieh, H Yoshinaga, T Muto, Waist-to-height ratio, a simple and practical index for assessing central fat distribution and metabolic risk in Japanese men and women. International Journal of Obesity. ,vol. 27, pp. 610- 616 ,(2003) , 10.1038/SJ.IJO.0802259
JOHN KANELLIS, DANIEL I FEIG, RICHARD J JOHNSON, Does asymptomatic hyperuricaemia contribute to the development of renal and cardiovascular disease? An old controversy renewed. Nephrology. ,vol. 9, pp. 394- 399 ,(2004) , 10.1111/J.1440-1797.2004.00336.X
Hsiao-Fen WENG, Yung-Chun OU, Thu-Hua LIU, Ji-Tseng FANG, Wen-Ko CHIOU, Jen-Der LIN, Correlation of the dysmetabolic risk factors with different anthropometric measurements. Endocrine Journal. ,vol. 52, pp. 139- 148 ,(2006) , 10.1507/ENDOCRJ.52.139
S. M. Haffner, H. Miettinen, M. P. Stern, The homeostasis model in the San Antonio Heart Study. Diabetes Care. ,vol. 20, pp. 1087- 1092 ,(1997) , 10.2337/DIACARE.20.7.1087
K CHIEN, H HSU, F SUNG, T SU, M CHEN, Y LEE, Hyperuricemia as a risk factor on cardiovascular events in Taiwan: The Chin-Shan Community Cardiovascular Cohort Study Atherosclerosis. ,vol. 183, pp. 147- 155 ,(2005) , 10.1016/J.ATHEROSCLEROSIS.2005.01.018
Miyao Matsubara, Hitoshi Chiba, Shoji Maruoka, Shinji Katayose, Elevated serum leptin concentrations in women with hyperuricemia. Journal of Atherosclerosis and Thrombosis. ,vol. 9, pp. 28- 34 ,(2002) , 10.5551/JAT.9.28
Richard J. Johnson, Salah D. Kivlighn, Yoon-Goo Kim, Shinichi Suga, Agnes B. Fogo, Reappraisal of the pathogenesis and consequences of hyperuricemia in hypertension, cardiovascular disease, and renal disease American Journal of Kidney Diseases. ,vol. 33, pp. 225- 234 ,(1999) , 10.1016/S0272-6386(99)70295-7
Narendra C. Bhalodkar, Steve Blum, Enas A. Enas, Accuracy of the Ratio of Triglycerides to High-Density Lipoprotein Cholesterol for Predicting Low-Density Lipoprotein Cholesterol Particle Sizes, Phenotype B, and Particle Concentrations Among Asian Indians American Journal of Cardiology. ,vol. 97, pp. 1007- 1009 ,(2006) , 10.1016/J.AMJCARD.2005.10.036
Abdulkerim Bedir, Murat Topbas, Fulya Tanyeri, Muhlise Alvur, and Nurol Arik, Leptin might be a regulator of serum uric acid concentrations in humans. Japanese Heart Journal. ,vol. 44, pp. 527- 536 ,(2003) , 10.1536/JHJ.44.527