Database support for top-down proteomics

摘要: Top-down proteomics is a revolutionary application for the identification and characterization of protein, known to be one most complicated challenging issues in biology. In top-down proteomics, quality speed data warehouse very important, as high accuracy results are returned by database search. ProSight Warehouse fills critical role PTM, first publicly available software suite. MySQL, free relational database, was base this warehouse. Many annotated predicted protein forms have been successfully incorporated into organismspecific integrated human strains. To achieve efficiency, schema (Absolute Mass Search), annotation methods (Shotgun Extended Shotgun Annotation), population strategies (on-the-fly population, bulk-loading method), integration methodology were developed. With successful implementation Warehouse, PTM achieved its aspiration, highly accurate characterization.