The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior

作者: Thomas R. Insel

DOI: 10.1016/J.NEURON.2010.03.005

关键词: Social neuroscienceOxytocin receptorPerceptionOxytocinSocial cognitionVasopressinAutismNeurosciencePsychologyForebrain

摘要: Social neuroscience is rapidly exploring the complex territory between perception and action where recognition, value, meaning are instantiated. This review follows trail of research on oxytocin vasopressin as an exemplar one path for "dark matter" social neuroscience. Studies across vertebrate species suggest that these neuropeptides important cognition, with gender- steroid-dependent effects. Comparative in voles yields a model based interspecies intraspecies variation geography receptors V1a forebrain. Highly affiliative have brain circuits related to reward or reinforcement. The neuroanatomical distribution may be guided by variations regulatory regions their respective genes. describes promises problems extrapolating findings human specific reference deficits autism.

参考文章(139)
Kyle L. Gobrogge, Yan Liu, Larry J. Young, Zuoxin Wang, Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 106, pp. 19144- 19149 ,(2009) , 10.1073/PNAS.0908620106
Gregor Domes, Markus Heinrichs, Jan Gläscher, Christian Büchel, Dieter F. Braus, Sabine C. Herpertz, Oxytocin Attenuates Amygdala Responses to Emotional Faces Regardless of Valence Biological Psychiatry. ,vol. 62, pp. 1187- 1190 ,(2007) , 10.1016/J.BIOPSYCH.2007.03.025
Joseph T. Glessner, Kai Wang, Guiqing Cai, Olena Korvatska, Cecilia E. Kim, Shawn Wood, Haitao Zhang, Annette Estes, Camille W. Brune, Jonathan P. Bradfield, Marcin Imielinski, Edward C. Frackelton, Jennifer Reichert, Emily L. Crawford, Jeffrey Munson, Patrick M. A. Sleiman, Rosetta Chiavacci, Kiran Annaiah, Kelly Thomas, Cuiping Hou, Wendy Glaberson, James Flory, Frederick Otieno, Maria Garris, Latha Soorya, Lambertus Klei, Joseph Piven, Kacie J. Meyer, Evdokia Anagnostou, Takeshi Sakurai, Rachel M. Game, Danielle S. Rudd, Danielle Zurawiecki, Christopher J. McDougle, Lea K. Davis, Judith Miller, David J. Posey, Shana Michaels, Alexander Kolevzon, Jeremy M. Silverman, Raphael Bernier, Susan E. Levy, Robert T. Schultz, Geraldine Dawson, Thomas Owley, William M. McMahon, Thomas H. Wassink, John A. Sweeney, John I. Nurnberger, Hilary Coon, James S. Sutcliffe, Nancy J. Minshew, Struan F. A. Grant, Maja Bucan, Edwin H. Cook, Joseph D. Buxbaum, Bernie Devlin, Gerard D. Schellenberg, Hakon Hakonarson, Autism genome-wide copy number variation reveals ubiquitin and neuronal genes Nature. ,vol. 459, pp. 569- 573 ,(2009) , 10.1038/NATURE07953
Lia Rosso, Laurent Keller, Henrik Kaessmann, Robert L Hammond, Mating system and avpr1a promoter variation in primates Biology Letters. ,vol. 4, pp. 375- 378 ,(2008) , 10.1098/RSBL.2008.0122
Adam S. Smith, Anders Ågmo, Andrew K. Birnie, Jeffrey A. French, Manipulation of the oxytocin system alters social behavior and attraction in pair-bonding primates, Callithrix penicillata Hormones and Behavior. ,vol. 57, pp. 255- 262 ,(2010) , 10.1016/J.YHBEH.2009.12.004
D. Pfaff, B. McEwen, Actions of estrogens and progestins on nerve cells Science. ,vol. 219, pp. 808- 814 ,(1983) , 10.1126/SCIENCE.6297008
Brett S. Abrahams, Daniel H. Geschwind, Advances in autism genetics: on the threshold of a new neurobiology Nature Reviews Genetics. ,vol. 9, pp. 341- 355 ,(2008) , 10.1038/NRG2346
Eric Hollander, Jennifer Bartz, William Chaplin, Ann Phillips, Jennifer Sumner, Latha Soorya, Evdokia Anagnostou, Stacey Wasserman, Oxytocin increases retention of social cognition in autism. Biological Psychiatry. ,vol. 61, pp. 498- 503 ,(2007) , 10.1016/J.BIOPSYCH.2006.05.030
Mario de Bono, David M. Tobin, M. Wayne Davis, Leon Avery, Cornelia I. Bargmann, Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli Nature. ,vol. 419, pp. 899- 903 ,(2002) , 10.1038/NATURE01169
James T. Winslow, Neuropeptides and non-human primate social deficits associated with pathogenic rearing experience. International Journal of Developmental Neuroscience. ,vol. 23, pp. 245- 251 ,(2005) , 10.1016/J.IJDEVNEU.2004.03.003