Reduced E-cadherin expression and enlargement of cancer nuclei strongly correlate with hematogenic metastasis in colorectal adenocarcinoma

摘要: BACKGROUND: Synchronous and metachronous hematogenic metastases are frequently detected in patients with colorectal carcinoma. Once these have developed, the prognoses of poor. Previously, we reported that enlargement cancer nuclei significantly correlated metastatic potential gastric hepatocellular Moreover, recently it has been reduced expression E-cadherin is associated tumor metastasis. To evaluate correlation between nuclear area (NA) cells E-cadherin, to elucidate whether factors correlate clinical outcome carcinoma, 105 consecutive were investigated. METHODS: In each case, NAs 600 analyzed by means a computer-assisted image analysis system was immunohistochemically an anti-E-cadherin monoclonal antibody. The levels divided into three groups according percentages E-cadherin-positive (level 0: positive 80%). RESULTS: mean NA tumors 57 microm2. enlarged proportion decrease 0, n = 48, 62 microm2; level 1, 35, microm2, 2, 22, 46 P 0.002). 10-year survival rates decreased (80% 64% 42% 0.004). rate 54 large (< or 36%) poorer than 51 small 80%, < 0.001). recognized as important predictor for prognosis Although not risk factor metastasis, 80% who developed metastasis had both expression. CONCLUSIONS: Detection carcinoma may reveal information