Prophylactic portal infusion chemotherapy as adjuvant therapy for the prevention of metachronous liver metastasis in colorectal cancer

摘要: The DNA ploidy and indices (DI) of 414 patients with colorectal cancer were analyzed, the incidence metachronous liver metastasis was found to be significantly higher in those aneuploid tumors a DI above 1.5 than below 1.4, or diploid equal 1.0. Next, confirm effectiveness administering prophylactic portal infusion chemotherapy (PPIC) as adjuvant therapy for prevention cancer, randomized controlled trial PPIC performed on 110 consecutive primary who had undergone curative resection. Although two study groups not different at 3.3% group 10.3% control group, aneuploidy lower group. These findings suggest that may have strong tendency metastasize liver, effective preventing such patients.