Flow cytometric examination of p53 protein in primary tumors and metastases to the liver and lymph nodes of colorectal cancer.
作者： Hisao Ito , Nobuaki Kaibara , Osamu Kimura , Kenji Sugamura , Tosihisa Kijima
DOI: 10.1007/BF02054534
关键词:
摘要: PURPOSE AND METHODS: To confirm prognostic significance of overexpression p53 in cases colorectal cancer, expression protein was examined by flow cytometry 113 cancer and its metastasis to the liver lymph nodes. RESULTS: Overexpression found 44 (39 percent) primary tumors. There were no significant correlations among level tumor, clinicopathologic features, prognosis cancer. detected 72 percent (18/25) metastases 40 (10/25) node metastases. Frequency samples that positive for significantly higher than tumors (P<0.01). By comparing with corresponding secondary tumors, a decrease more 5 fluorescence index, compared not but 20 Incidence lower p53, (32 (8 percent;P<0.05). CONCLUSIONS: From these results, it seems possible may be good indicator influenced environments tumor.
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