Lack of toxicity and carcinogenicity of some commonly used cutaneous agents
作者： Frej Stenbäck , Philippe Shubik
DOI: 10.1016/0041-008X(74)90242-7
关键词: Pathology 、 Carcinogen 、 Isopropyl myristate 、 Chemical treatment 、 Tumor incidence 、 Chemistry 、 Lung 、 Inflammation 、 Skin lesion 、 Toxicity
摘要: Abstract The potential carcinogenicity and toxicity of several commonly used cutaneous agents (benzophenone, propylene glycol, isopropyl myristate, resorcinol, 2-ethyl-1,3-hexanediol, p-aminobenzoic acid pyrogallol) were studied in female Swiss mice by administering repeated applications the chemicals on skin for life-span animals. Tumors seen both control treated animals mainly lymphomas, hemangiomas liver lung adenomas, as well tumors other organs. A statistically significant increase tumor incidence caused chemical treatment was not seen. Skin lesions, slight inflammation ulceration seen, but no persistent abnormalities occurred. few areas untreated Thus a carcinogenic or toxic which would affect use these man detected.
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