The new functions of the gut in the control of glucose homeostasis.

摘要: PURPOSE OF REVIEW It has become clear during the past few years that intestine is more than a digestive tract. In addition to its role as subtle endocrine organ, participation in endogenous glucose production, property so far believed be restricted liver and kidney, been emphasized. RECENT FINDINGS The of gut regulation homeostasis received further experimental accreditation from both animal human studies. relation molecular mechanisms control production potential regulatory glutaminase glycerokinase suggested studies fasting, transcription glucose-6 phosphatase gene specified an intestinal context. Furthermore, two newly described metabolic pathways accounting for transepithelial transport have support: lumen inside enterocyte, involving translocation transporter Glut2 apical membrane, enterocyte into blood, 6-phosphatase independent Glut2. SUMMARY new knowledge regarding glucose, glutamine, glycerol metabolisms small should interest those who care diabetic or septic patients, are involved nutrition research humans. They also importance inherited genetic deficiencies, such glycogen storage disease type 1 (Von Gierke disease) Fanconi-Bickel glucose-galactose malabsorption syndromes.