Fetal Surgery for Congenital Diaphragmatic Hernia Is Back from Never Gone

作者: Jan A. Deprest , Kypros Nicolaides , Eduard Gratacos

DOI: 10.1159/000322844

关键词: FetoscopyPulmonary hypoplasiaCongenital diaphragmatic herniaSurgeryPercutaneousFetal surgeryFetal interventionMedicineDiaphragmatic herniaRandomized controlled trial

摘要: Over half of the cases congenital diaphragmatic hernia are picked up prenatally. Prenatal assessment aims to rule out associated anomalies and make an individual prognosis. Prediction outcome is based on measurements lung size vasculature as well liver herniation. A subset fetuses likely die in postnatal period eligible for a fetal intervention that can promote growth. Two randomized trials have shown surgery using open anatomical repair or tracheal occlusion via hysterostomy has no benefit. Since then, percutaneous fetoscopic technique been introduced, which be safe seems improve survival when compared historical controls. Rupture membranes early delivery, nevertheless, remain issue, but less earlier experience. Improved outcomes confirmed two other studies published this issue Fetal Diagnosis Therapy. This paper summarizes experimental clinical history hernia. It stresses need another trial. trial started Europe patients should asked whether they would like participate.

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