Role of urinary beta-glucuronidase in human bladder cancer.

摘要: It has been suggested that high levels of urinary beta-glucuronidase may increase an individual's risk bladder cancer by releasing free carcinogens from their inactive glucuronide conjugates in the bladder. The hypothesis derives part observed patients. Because most individual variation and other lysosomal enzymes normal population is genetically determined, we would expect that, if glucuronidase were a predisposing factor disease, patients transmit this trait to progeny. We have tested find three enzymes, alpha-galactosidase, beta-galactosidase, beta-hexosaminidase, are not significantly elevated 34 progeny compared matched controls. Additionally, 15 judged be disease for median time 5 years did when 125 individuals. Thus, likely consequence rather than cause.