Association of apolipoprotein B XbaI gene polymorphism and lipid profile in northern Indian obese.

摘要: Background: Over the last few decades, obesity, diabetes, and hypertension have become main health evils. The problems of obesity are well-recognized. However, fact that all obese individuals not at same risk developing a disease is also recognized. apolipoprotein B (APOB) plays central role in lipid metabolism. So we compare association APOB XbaI gene polymorphism profile total north Indian population. Materials Methods: A 132 (body mass index [BMI] >25 kg/m 2 ) age matched non-obese (BMI ≤ 25 subjects were studied after taking detailed clinical profile. Lipid serum/plasma was done using commercial kits. Genetic analysis Polymerase Chain Reaction-Restriction Fragment Leanth (PCR-RFLP). Statistical Analysis: performed by Package for Social Sciences (SPSS) (version 11.5) software (IBM Corporation). All continuous variables expressed as mean ± SD tested variance test. Comparisons categorical assessed χ tests or Fisher's exact P Results: Analysis showed had significantly higher value waist-to-hip ratio, blood pressure (systolic diastolic), In polymorphism, did find significant differences genotype allele frequencies. Moreover, none metabolic parameters (lipid profile) any with polymorphism. Conclusions: Study reveals no considerable Indians.