HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis
作者： Dan Liang , Maowei Yang , Baolei Guo , Lei Yang , Junjun Cao
DOI: 10.1007/S00432-012-1256-5
关键词: Cancer cell 、 Osteosarcoma 、 Elemene 、 Cancer research 、 Ovarian carcinomas 、 Apoptosis 、 Endocrinology 、 Internal medicine 、 Lung 、 Prostate 、 Hematology 、 Medicine
摘要: Background β-Elemene, isolated from more than 50 Chinese herbs and plants, has shown promising anticancer effects against a broad spectrum of tumors, such as lung, breast, prostate, cervical, colon ovarian carcinomas (Wang et al. in Cell Mol Life Sci 62:881–893, 2005; Li 62:894–904, J Pharm Pharmacol 62(8):1018–1027, 2010). But it not reported osteosarcoma cells. The aim the present study is to investigate antitumor effect β-elemene on human cancer cells molecular mechanism involved.
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sci-hub.se 参考文章(34)
Ling-Zhi Liu, Yi Jing, Lisa L. Jiang, Xiu-E. Jiang, Yue Jiang, Yongyut Rojanasakul, Bing-Hua Jiang, Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway. Biochemical and Biophysical Research Communications. ,vol. 413, pp. 299- 305 ,(2011) , 10.1016/J.BBRC.2011.08.091
Chia-Hung Hsieh, Cheng-Hung Lee, Ji-An Liang, Chun-Yen Yu, Woei-Cherng Shyu, Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity Oncology Reports. ,vol. 24, pp. 1629- 1636 ,(2010) , 10.3892/OR_00001027
Youn Ju Lee, Nam-Yi Kim, Young-Ah Suh, ChuHee Lee, Involvement of ROS in Curcumin-induced Autophagic Cell Death The Korean Journal of Physiology and Pharmacology. ,vol. 15, pp. 1- 7 ,(2011) , 10.4196/KJPP.2011.15.1.1
Jinshun Zhao, Qingdi Li, Baobo Zou, Gangduo Wang, Xiping Li, Jee Kim, Christopher Cuff, Lan Huang, Eddie Reed, Kevin Gardner, In vitro combination characterization of the new anticancer plant drug β-elemene with taxanes against human lung carcinoma International Journal of Oncology. ,vol. 31, pp. 241- 252 ,(2007) , 10.3892/IJO.31.2.241
Seong-Hee Lee, Kyung Hee Koo, Jong-Wan Park, Hee-Jung Kim, Sang-Kyu Ye, Jong Bae Park, Byung-Kiu Park, Yong-Nyun Kim, HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress Carcinogenesis. ,vol. 30, pp. 1997- 2004 ,(2009) , 10.1093/CARCIN/BGP233
Shih-Chieh Lin, Chun-Wei Chien, Jenq-Chang Lee, Yi-Chun Yeh, Keng-Fu Hsu, Yen-Yu Lai, Shao-Chieh Lin, Shaw-Jenq Tsai, Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells. Journal of Clinical Investigation. ,vol. 121, pp. 1905- 1916 ,(2011) , 10.1172/JCI44362
Adetola B Adesida, Lisa M Grady, Wasim S Khan, S Jane Millward-Sadler, Donald M Salter, Timothy E Hardingham, Human meniscus cells express hypoxia inducible factor-1α and increased SOX9 in response to low oxygen tension in cell aggregate culture Arthritis Research & Therapy. ,vol. 9, pp. 1- 9 ,(2007) , 10.1186/AR2267
J Yuan, Z L Gu, W H Chou, C Y Kwok, Elemene induces apoptosis and regulates expression of bcl-2 protein in human leukemia K562 cells. Acta Pharmacologica Sinica. ,vol. 20, pp. 103- 106 ,(1999)
Giulia Ottaviani, Norman Jaffe, The Epidemiology of Osteosarcoma Cancer treatment and research. ,vol. 152, pp. 3- 13 ,(2009) , 10.1007/978-1-4419-0284-9_1
Adrian Staab, Markus Fleischer, Juergen Loeffler, Harun M. Said, Astrid Katzer, Christian Plathow, Herrmann Einsele, Michael Flentje, Dirk Vordermark, Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro. Strahlentherapie Und Onkologie. ,vol. 187, pp. 252- 259 ,(2011) , 10.1007/S00066-011-2167-0