mTOR: An attractive therapeutic target for osteosarcoma?

摘要: // Liu Ding 1,* , Congwei Qing Bei 2 Yang Tao 3 Wang Ruiguo 4 Yu Heze Dou Bo and Li Zhihong 1 Department of Orthopaedics, The Second Xiangya Hospital Central South University, Changsha, Hunan, China Thoracic Surgery, Otolaryngology, Head Neck Clinical Medicine for Eight-Year-Program, Xiangya School Medicine, * These authors have contributed equally to this work Correspondence to: Zhihong, email: Keywords : osteosarcoma, mTOR, target, autophagy, apoptosis Received January 14, 2016 Accepted May 05, Published 11, Abstract Osteosarcoma (OS) is a common primary malignant bone tumor with high morbidity mortality in children young adults. How improve poor prognosis OS due resistance chemotherapy remains challenge. Recently, growing findings show activation mammalian target rapamycin (mTOR), associated cell growth, proliferation, metastasis. Targeting mTOR may be promising therapeutic approach treating OS. This review summarizes the roles pathway present research status inhibitors context In addition, we attempted discuss how design better treatment project by combining inhibitor other drugs.