Ubiquitin signalling in the NF-κB pathway
作者： Zhijian J. Chen
DOI: 10.1038/NCB0805-758
关键词: Deubiquitination 、 Cell biology 、 Enhancer binding 、 Transcription factor 、 CHUK 、 NF-κB 、 I-Kappa-B Kinase 、 IκB kinase 、 Chemistry 、 MAP kinase kinase kinase
摘要: The transcription factor NF-kappaB (nuclear kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the pathway: degradation of IkappaB (inhibitor NF-kappaB), processing precursors, activation kinase (IKK). Recent studies have revealed several enzymes involved ubiquitination deubiquitination signalling proteins that mediate IKK through a degradation-independent mechanism.
unirioja.es
nature.com
elsevier.com
sci-hub.se 参考文章(84)
Zhijian J. Chen, Tom Maniatis, Role of the Ubiquitin—Proteasome Pathway in NF-κB Activation Springer, Boston, MA. pp. 303- 322 ,(1998) , 10.1007/978-1-4899-1922-9_10
U. Senftleben, Activation by IKKalpha of a Second, Evolutionary Conserved, NF-kappa B Signaling Pathway Science. ,vol. 293, pp. 1495- 1499 ,(2001) , 10.1126/SCIENCE.1062677
Hong Ye, Young Chul Park, Jee Y. Chung, Hao Wu, All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction Journal of Cell Science. ,vol. 115, pp. 679- 688 ,(2002) , 10.1242/JCS.115.4.679
Naohiro Inohara, Gabriel Nuñez, NODs: intracellular proteins involved in inflammation and apoptosis. Nature Reviews Immunology. ,vol. 3, pp. 371- 382 ,(2003) , 10.1038/NRI1086
Jianhua Yang, Yong Lin, Zijian Guo, Jinke Cheng, Jianyi Huang, Li Deng, Warren Liao, Zhijian Chen, Zheng-gang Liu, Bing Su, The essential role of MEKK3 in TNF-induced NF-κB activation Nature Immunology. ,vol. 2, pp. 620- 624 ,(2001) , 10.1038/89769
Jun Ninomiya-Tsuji, Kazuya Kishimoto, Atsushi Hiyama, Jun-ichiro Inoue, Zhaodan Cao, Kunihiro Matsumoto, The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway Nature. ,vol. 398, pp. 252- 256 ,(1999) , 10.1038/18465
Jin Jiang, Gary Struhl, Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb Nature. ,vol. 391, pp. 493- 496 ,(1998) , 10.1038/35154
Chen Wang, Li Deng, Mei Hong, Giridhar R Akkaraju, Jun-ichiro Inoue, Zhijian J Chen, None, TAK1 is a ubiquitin-dependent kinase of MKK and IKK Nature. ,vol. 412, pp. 346- 351 ,(2001) , 10.1038/35085597
N. S. C. van Oers, CELL BIOLOGY: Kinasing and Clipping Down the NF- B Trail Science. ,vol. 308, pp. 65- 66 ,(2005) , 10.1126/SCIENCE.1110902
J. T. Winston, P. Strack, P. Beer-Romero, C. Y. Chu, S. J. Elledge, J. W. Harper, The SCFβ-TRCP–ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IκBα and β-catenin and stimulates IκBα ubiquitination in vitro Genes & Development. ,vol. 13, pp. 270- 283 ,(1999) , 10.1101/GAD.13.3.270