Apoptosis of skeletal muscles during development and disease.

摘要: Cells from multicellular organisms self-destroy when no longer needed or damaged. They do this by activating genetically controlled machineries that lead to apoptosis. Skeletal muscles in adult animals are fully differentiated syncytial cells. Apoptosis has been described developing and, recently, skeletal muscle. The cellular and molecular aspects of myoblast myofibre apoptosis their role disease analysed review. Alterations the pathways regulate myoblasts proliferation/differentiation induction during myogenesis both vivo vitro. In muscle myofibres seems start segmental areas often producing loss a single myonucleus. bcl2/bax system is active occurs. On other hand conflicting results reported on played FasL/Fas system. These findings confirmed vitro myotubes susceptibility Though shown occur muscle, diseases pattern followed myogenic cells far being clear.