Associations between EBV serostatus and organ transplant type in PTLD risk: an analysis of the SRTR National Registry Data in the United States.
作者： V. R. Dharnidharka , K. E. Lamb , J. A. Gregg , H.-U. Meier-Kriesche
DOI: 10.1111/J.1600-6143.2011.03893.X
关键词: Gastroenterology 、 Internal medicine 、 Hazard ratio 、 Lymphoproliferative disorders 、 Serostatus 、 National registry 、 Organ transplantation 、 Medicine 、 Survival rate 、 Immunology 、 Increased risk 、 Single Center
摘要: In a prior multiorgan transplant database study, recipient Epstein-Barr virus (EBV) seronegativity was not associated with increased risk for posttransplant lymphoproliferative disorders (PTLD) in liver transplants (LTX), at variance single center reports and data from kidney heart (KTX HTX). The Scientific Registry of Transplant Recipients (SRTR) the United States is only other registry on required variables comparison.Our study set comprised 112 756 KTX (580 PTLDs; 0.51%), 13 937 HTX (140 1.0%) 40 437 LTX (383 0.95%) performed January 2003 onward. unadjusted hazard ratio (HR) PTLD if EBV seronegative 5.005 KTX, 6.528 2.615 (p < 0.001 all). models adjusted multiple covariates, HR 3.583 0.001) 4.037 HTX, 1.479 = 0.03) LTX. Interaction using seropositive as reference group showed significantly higher all organ groups also (AHR 2.053, p 0.0001).Recipient still LTX, though less so because baseline group.
sci-hub.se 参考文章(28)
T. M. Habermann, C. V. Paya, C. G.A. McGregor, R. H. Wiesner, J. G. Strickler, R. C. Daly, W. F. Marshall, J. A. Velosa, R. C. Walker, Pretransplantation seronegative Epstein-Barr virus status is the primary risk factor for posttransplantation lymphoproliferative disorder in adult heart, lung, and other solid organ transplantations. Journal of Heart and Lung Transplantation. ,vol. 14, pp. 214- 221 ,(1995)
Vikas R. Dharnidharka, Epidemiology of PTLD Post-Transplant Lymphoproliferative Disorders. pp. 17- 28 ,(2010) , 10.1007/978-3-642-01653-0_3
W. K. Kremers, H. C. Devarbhavi, R. H. Wiesner, R. A. F. Krom, W. R. Macon, T. M. Habermann, Post-transplant lymphoproliferative disorders following liver transplantation: incidence, risk factors and survival. American Journal of Transplantation. ,vol. 6, pp. 1017- 1024 ,(2006) , 10.1111/J.1600-6143.2006.01294.X
Himisha Patel, Dan T. Vogl, Nicole Aqui, Abraham Shaked, Kim Olthoff, James Markmann, Rajender Reddy, Edward A. Stadtmauer, Stephen Schuster, Donald E. Tsai, Posttransplant lymphoproliferative disorder in adult liver transplant recipients: a report of seventeen cases. Leukemia & Lymphoma. ,vol. 48, pp. 885- 891 ,(2007) , 10.1080/10428190701223275
Gerhard Opelz, Volker Daniel, Cord Naujokat, Bernd Döhler, Epidemiology of pretransplant EBV and CMV serostatus in relation to posttransplant non-Hodgkin lymphoma Transplantation. ,vol. 88, pp. 962- 967 ,(2009) , 10.1097/TP.0B013E3181B9692D
Kenneth A. Newell, Estella M. Alonso, Peter F. Whitington, David S. Bruce, J. Michael Millis, James B. Piper, E. Steve Woodle, Susan M. Kelly, Hartmut Koeppen, John Hart, Charles M. Rubin, J. Richard Thistlethwaite, Posttransplant lymphoproliferative disease in pediatric liver transplantation : Interplay between primary Epstein-Barr virus infection and immunosuppression Transplantation. ,vol. 62, pp. 370- 375 ,(1996) , 10.1097/00007890-199608150-00012
Christophe Hézode, Christophe Duvoux, Georgios Germanidis, Françoise Roudot-Thoraval, Anne-Laure Vincens, Philippe Gaulard, Daniel Cherqui, Jean-Michel Pawlotsky, Daniel Dhumeaux, Role of hepatitis C virus in lymphoproliferative disorders after liver transplantation Hepatology. ,vol. 30, pp. 775- 778 ,(1999) , 10.1002/HEP.510300314
Jean Bernard Otte, Etienne Marc Sokal, Henedina Antunes, Claire Beguin, Monique Bodeus, Pierre Wallemacq, Jean de Ville de Goyet, Raymond Reding, Magda Janssen, Jean Paul Buts, Early signs and risk factors for the increased incidence of Epstein-Barr virus-related posttransplant lymphoproliferative diseases in pediatric liver transplant recipients treated with tacrolimus. Transplantation. ,vol. 64, pp. 1438- 1442 ,(1997) , 10.1097/00007890-199711270-00011
L. Wu, D. C. Rappaport, A. Hanbidge, N. Merchant, F. A. Shepherd, P. D. Greig, Lymphoproliferative disorders after liver transplantation : imaging features Abdominal Imaging. ,vol. 26, pp. 200- 206 ,(2001) , 10.1007/S002610000130
B. Z. Katz, E. Pahl, S. E. Crawford, M. C. Kostyk, S. Rodgers, R. Seshadri, M. Proytcheva, S. Pophal, Case-control study of risk factors for the development of post-transplant lymphoproliferative disease in a pediatric heart transplant cohort. Pediatric Transplantation. ,vol. 11, pp. 58- 65 ,(2007) , 10.1111/J.1399-3046.2006.00609.X