Influence of Posttransplant Lymphoproliferative Disorder on Survival in Children After Heart Transplantation

摘要: The influence of posttransplant lymphoproliferative disorder (PTLD) on long-term survival in children after heart transplantation (HTx) is not well studied. United Network for Organ Sharing database was queried from 1987 to 2013 data PTLD relation induction immunosuppression and recipient Epstein-Barr virus status (<18 years age) who underwent HTx. Of 6818 first-time pediatric transplants, 5169 had follow-up malignancy, with 360 being diagnosed PTLD. Univariate Cox analysis identified diminished onset using a time-varying measure (HR 2.208; 95 % CI 1.812, 2.689; p < 0.001), although Kaplan-Meier functions found no difference between the group ever non-PTLD reference (log-rank test: χ 1 (2)  = 0.02; p = 0.928). A multivariate model greater mortality hazard associated development adjusting EBV seronegativity other covariates 3.024; 1.902, 4.808; p < 0.001). Induction at time HTx did significantly mortality. adversely influenced confounding variables.