Endothelium‐dependent inhibition of platelet aggregation
作者： Hiroshi Azuma , Masayuki Ishikawa , Satomi Sekizaki
DOI: 10.1111/J.1476-5381.1986.TB10218.X
关键词: Pharmacology 、 Endothelium 、 Biochemistry 、 Arachidonic acid 、 Vasodilation 、 Chemistry 、 Nordihydroguaiaretic acid 、 Thoracic aorta 、 Platelet 、 Acetylcholine 、 Aorta
摘要: 1In cascade perfusion and superfusion experiments on rabbit tissues, when acetylcholine (ACh) was introduced into the circuit so as to perfuse aorta under with noradrenaline (NA), effluent relaxed transverse aortic strip which had been denuded of endothelium. 2The from perfused capable relaxing also significantly inhibited platelet aggregation induced by arachidonic acid (AA) in a volume-related manner. The inhibitory activity decreased prolongation transit time before addition platelet-rich plasma. 3Neither inhibition AA-induced nor relaxation could be observed after removal endothelium aorta, or pretreatment mepacrine nordihydroguaiaretic (NDGA). 4The unaffected platelets NDGA at concentration tested. 5Pretreatment indomethacin failed modify effluent. 6These results strongly suggest that endothelium-derived vascular relaxant factor (EDRF) possesses its vasodilator activity.
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