Increased GABA concentrations in type 2 diabetes mellitus are related to lower cognitive functioning.
作者： Frank C.G. van Bussel , Walter H. Backes , Paul A.M. Hofman , Nicolaas A.J. Puts , Richard A.E. Edden
DOI: 10.1097/MD.0000000000004803
关键词: Neurotransmitter 、 GABAergic 、 Medicine 、 Type 2 Diabetes Mellitus 、 Glutamate receptor 、 Type 2 diabetes 、 Internal medicine 、 Diabetes mellitus 、 Endocrinology 、 Cognitive decline 、 gamma-Aminobutyric acid
摘要: Type 2 diabetes mellitus is associated with accelerated cognitive decline. The underlying pathophysiological mechanisms still remain to be elucidated although it known that insulin signaling modulates neurotransmitter activity, including inhibitory γ-aminobutyric acid (GABA) and excitatory glutamate (Glu) receptors. Therefore, we examined whether levels of GABA Glu are related status performance.Forty-one participants type 39 without underwent detailed assessments 3-Tesla proton MR spectroscopy. associations neurotransmitters performance were using multivariate regression analyses controlling for age, sex, education, BMI, percentage gray/white matter ratio in spectroscopic voxel.Analysis revealed higher GABA+ diabetes, fasting blood glucose HbA1c levels, both high less performance.To conclude, have alterations the GABAergic system, which lower functioning, hint at involvement an metabolic mechanism.
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