Tissue correction for GABA-edited MRS: Considerations of voxel composition, tissue segmentation, and tissue relaxations.

摘要: Purpose To develop a tissue correction for GABA-edited magnetic resonance spectroscopy (MRS) that appropriately addresses differences in voxel gray matter (GM), white (WM), and cerebrospinal fluid (CSF) fractions. Materials Methods Simulations compared the performance of approaches. Corrections were then applied to vivo data from 16 healthy volunteers, acquired at 3T. GM, WM, CSF fractions determined T1-weighted images. content, GM/WM GABA water relaxation three compartments are combined into single, fully corrected measurement. Results Simulations show increases dependence measurements on fraction, by an amount equal fraction CSF. Furthermore, GM substantially (and nonlinearly) example, factor over four when is 50%. At this overestimated 1.5. For data, correcting composition increased measured values (P   0.5 all regions). Corrected differ significantly based segmentation procedure used (P < 0.0001) parameter assumptions made (P < 0.0001). Conclusion We introduce comprehensive adjusts correct different compositions J. Magn. Reson. Imaging 2015;42:1431–1440.