Human mesothelin chimeric antigen receptors and uses thereof
作者： Carl H. June , Gregory Beatty , Boris Engels , Huijuan Song , Qilong Wu
DOI:
关键词: Molecular biology 、 Chimeric antigen receptor 、 Mesothelin 、 Recombinant DNA 、 Genetically modified organism 、 Binding domain 、 T cell 、 Biology
摘要: Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided a chimeric antigen receptor(CAR) specific to mesothelin, vectors encoding the same, recombinant T cells comprising mesothelin CAR. Further administering genetically modified cell expressing CAR that comprises binding domain.
lens.org参考文章(321)
Jian Liu, Scott Quenton Harper, Sara Garwick, Lindsay Wallace, Recombinant Virus Products and Methods for Inhibition of Expression of DUX4 ,(2012)
Herman Waldmann, Kathleen Nolan, Lynn Poulton, Treatment of obesity ,(2010)
Richard S. Blumberg, Yu-Hwa Huang, Nalan Utku, Anti-ceacam1 recombinant antibodies for cancer therapy ,(2012)
Solomon Langermann, Simultaneous inhibition of pd-l1/pd-l2 ,(2010)
Juliane Jürgensmeier, Georgina Speake, Combination therapy 238 ,(2009)
Gary Koretzky, Steven M. Albelda, Matthew Riese, Liang-Chuan Wang, Inhibition of Diacylglycerol Kinase to Augment Adoptive T cell Transfer ,(2013)
Gianpietro Dotti, Cliona M. Rooney, David M. Spencer, Malcolm K. Brenner, Engineered cd19-specific t lymphocytes that coexpress il-15 and an inducible caspase-9 based suicide gene for the treatment of b-cell malignancies ,(2012)
Carl H. June, Yangbing Zhao, Xiaojun Liu, Enhancing activity of car t cells by co-introducing a bispecific antibody ,(2013)
Veena R. Agarwal, Nishigandha Naik, Robert Zahler, Bichismita Sahu, Sanjay Kumar, Rajiv Sharma, Substituted imidazoquinoline derivatives as kinase inhibitors ,(2011)
Claudia Rossig, Cliona Rooney, Malcolm Brenner, Bi-spcific chimeric T cells ,(2002)