The effects of glycerol on vestibular function and the endolymphatic sac after pre-treatment with colchicine.

摘要: The endolymphatic sac (ES) is believed to absorb endolymph. Recent studies have suggested that the ES also has a secretory capacity, function may be related regulation of inner ear fluid volume and pressure. Other indicate hyperosmo-lar substances, such as glycerol urea, initiate secretion glycoprotein into ES. This was regulatory by which it can compensate for decrease in endolymph In order investigate this potential ES, effect on investigated with or without presence pharmacological inhibition through colchicine treatment. Animals treated way showed marked signs impaired function, including loss postural control Preyer's reflex. Significant ultra-structural changes were noted suggesting disturbed activity. results the...