RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro
作者： Michael J Rogers , Karen A Sutherland , Helena L Rogers , Denise Tosh
DOI: 10.1186/AR2681
关键词: RANK Ligand 、 Endocrinology 、 Zoledronic acid 、 Cancer research 、 Cytokine receptor 、 Osteoclast 、 RANKL 、 Clodronic acid 、 Bisphosphonate 、 Bone resorption 、 Internal medicine 、 Medicine
摘要: Introduction Bisphosphonates are the most widely used class of drug for inhibiting osteoclast-mediated bone loss, but their effectiveness at preventing joint destruction in rheumatoid arthritis has generally been disappointing. We examined whether ability bisphosphonates to induce osteoclast apoptosis and inhibit resorption vitro is influenced by cytokine receptor activator nuclear factor-kappa B ligand (RANKL), an important mediator inflammation-induced loss.
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