Effects of antithrombin III (AT III) and Trp49-modified AT III on plasma level of 6-keto-PGF1α in rats
作者： Mitsuhiro Uchiba , Kenji Okajima , Kazunori Murakami , Hiroaki Okabe , Kiyoshi Takatsuki
DOI: 10.1016/0049-3848(95)00168-Q
关键词: Prostacyclin 、 Biochemistry 、 Internal medicine 、 Glycosaminoglycan 、 Antithrombin 、 Heparin 、 Endothelial stem cell 、 Chemistry 、 Blood plasma 、 Endocrinology 、 In vivo 、 Thrombin
摘要: We evaluated the effect of antithrombin III (AT III) on plasma level 6-keto-PGF1α in rats to determine whether AT may promote release prostacyclin (PGI2) from endothelial cells vivo. The intravenous administration (250U/kg) significantly increased levels 6-keto-PGF1α, with a peak seen 90 min post-administration. Neither Trp49-modified III, which lacks affinity for heparin but retains an inhibitory capacity thrombin, nor plus after administration. Indomethacin pretreatment inhibited increase produced by III. Observations suggest that PGI2 interacting heparin-like glycosaminoglycans vivo, consistent previous observations cultured cells.
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