Antithrombin III reduces renal ischemia-reperfusion injury in rats.
作者： A Bilgihan , Akın Özden , E Duzcan , Neşe Çallı Demirkan , A Sarioglu
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摘要: Few studies have pointed out the relationship between ischemia-reperfusion (IR) injury and coagulation system. Antithrombin III (AT) has anti-inflammatory effects in IR injury. We investigated effect of AT supplementation on renal rats achieved by clamping left pedicle for 60 min subsequent 24-h reperfusion after right nephrectomy. Sprague-Dawley were divided into three groups: sham-operated (no injury), ischemic controls, an AT-treated group (250 U/kg before reperfusion). Creatinine values, tissue malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity, histopathological damage 24 h reperfusion. In addition, 7-day survival rates each evaluated. MDA levels MPO activity significantly elevated was more severe controls than sham (P<0.05). lower there less controls. Accumulation lipid peroxidation products neutrophils inhibited treatment. conclude that may attenuate rats.
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