Assessing functional performance in the mdx mouse model.

摘要: Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder for which no cure available. Nevertheless, several potential pharmaceutical compounds gene therapy approaches have progressed into clinical trials. With improvement in function being the most important end point these trials, lot of emphasis has been placed on setting up reliable, reproducible, easy to perform functional tests pre clinically assess function, strength, condition, coordination mdx mouse model DMD. Both invasive noninvasive are Tests that do not exacerbate disease can be used determine natural history effects therapeutic interventions (e.g. forelimb grip strength test, two different hanging using either wire or grid rotarod running). Alternatively, forced treadmill running enhance progression and/or protective pathology. We here describe how commonly reliable reproducible manner. Using protocols based standard operating procedures enables comparison data between laboratories.