Apolipoprotein E mimetic peptide, CN-105, improves outcomes in ischemic stroke.
作者： Tian Ming Tu , Brad J. Kolls , Erik J. Soderblom , Viviana Cantillana , Paul Durham Ferrell
DOI: 10.1002/ACN3.399
关键词:
摘要: Objective At present, the absence of a pharmacological neuroprotectant represents an important unmet clinical need in the treatment of ischemic and traumatic brain injury. Recent evidence suggests that administration of apolipoprotein E mimetic therapies represent a viable therapeutic strategy in this setting. We investigate the neuroprotective and anti‐inflammatory properties of the apolipoprotein E mimetic pentapeptide, CN‐105, in a microglial cell line and murine model of ischemic stroke. Methods Ten to 13‐week‐old male …
sci-hub.se 参考文章(82)
Karl H. Weisgraber, Apolipoprotein E: Structure-Function Relationships Advances in Protein Chemistry. ,vol. 45, pp. 249- 302 ,(1994) , 10.1016/S0065-3233(08)60642-7
Gunjan D. Manocha, Kendra L. Puig, Susan A. Austin, Kathleen Seyb, Marcie A. Glicksman, Colin K. Combs, Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis PLOS ONE. ,vol. 10, pp. e0132604- ,(2015) , 10.1371/JOURNAL.PONE.0132604
Barry W McColl, Ailsa L McGregor, Andrew Wong, Julian D Harris, Andrea Amalfitano, Sandra Magnoni, Andrew H Baker, George Dickson, Karen Horsburgh, APOE ε3 Gene Transfer Attenuates Brain Damage after Experimental Stroke Journal of Cerebral Blood Flow and Metabolism. ,vol. 27, pp. 477- 487 ,(2007) , 10.1038/SJ.JCBFM.9600361
Diana Amantea, Giuseppe Nappi, Giorgio Bernardi, Giacinto Bagetta, Maria T. Corasaniti, Post‐ischemic brain damage: pathophysiology and role of inflammatory mediators FEBS Journal. ,vol. 276, pp. 13- 26 ,(2009) , 10.1111/J.1742-4658.2008.06766.X
Nassia Methia, Patrick André, Ali Hafezi-Moghadam, Maria Economopoulos, Kennard L. Thomas, Denisa D. Wagner, ApoE deficiency compromises the blood brain barrier especially after injury. Molecular Medicine. ,vol. 7, pp. 810- 815 ,(2001) , 10.1007/BF03401973
Amanda G. Thrift, Dominique A. Cadilhac, Tharshanah Thayabaranathan, George Howard, Virginia J. Howard, Peter M. Rothwell, Geoffrey A. Donnan, Global Stroke Statistics International Journal of Stroke. ,vol. 9, pp. 6- 18 ,(2014) , 10.1111/IJS.12245
Fang Cao, Yong Jiang, Yue Wu, Jianjun Zhong, Jieshi Liu, Xinghu Qin, Ligang Chen, Michael P Vitek, Fengqiao Li, Lu Xu, Xiaochuan Sun, None, Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury Journal of Neurotrauma. ,vol. 33, pp. 175- 182 ,(2016) , 10.1089/NEU.2015.3887
Huaxin Sheng, Daniel T. Laskowitz, G. Burkhard Mackensen, Masaya Kudo, Robert D. Pearlstein, David S. Warner, Apolipoprotein E Deficiency Worsens Outcome From Global Cerebral Ischemia in the Mouse Stroke. ,vol. 30, pp. 1118- 1124 ,(1999) , 10.1161/01.STR.30.5.1118
Joseph M Dal Porto, Stephen B Gauld, Kevin T Merrell, David Mills, Aimee E Pugh-Bernard, John Cambier, B cell antigen receptor signaling 101. Molecular Immunology. ,vol. 41, pp. 599- 613 ,(2004) , 10.1016/J.MOLIMM.2004.04.008
Lesli E. Skolarus, William J. Meurer, Krithika Shanmugasundaram, Eric E. Adelman, Phillip A. Scott, James F. Burke, Marked Regional Variation in Acute Stroke Treatment Among Medicare Beneficiaries Stroke. ,vol. 46, pp. 1890- 1896 ,(2015) , 10.1161/STROKEAHA.115.009163