Continuous production of acrylamide using immobilized Brevibacterium sp. CH2 in a two-stage packed bed reactor
作者： Cheo Young Lee , Ho Nam Chang
DOI: 10.1007/BF01028487
关键词: Packed bed 、 Bioreactor 、 Brevibacterium sp. 、 Brevibacterium 、 Acrylonitrile 、 Chemistry 、 Continuous production 、 Chromatography 、 Acrylamide 、 Nitrile hydratase
摘要: Acrylamide was enzymatically produced from acrylonitrile (AN) in a two-stage packed bed reactor with immobilizedBrevibacterium sp. CH2 cells. Continuous production became possible because of higher tolerance nitrile hydratase respect to 6% AN than either the CH1 enzyme or theCorynebacterium Nitto Chemical Industry which rapidly deactivated solution 3% AN. The maximum volumetric productivity 93.2 g/(L.h) obtained when fed at 4 °C, compares that 8.3
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