Anorexigenic Peptides in Health and Disease

摘要: The regulation of satiety and body weight involves highly complex multiple interactions between the gastrointestinal tract, adipose tissue central nervous system. Several neuropeptides released by hypothalamic neurons including corticotropin-releasing factor, α-melanocyte stimulating hormone, corticotropin, brain-derived neurotrophic cocaine- amphetamine-regulated transcript, B, W nesfatin-1; hormones obestatin, pancreatic polypeptide, amylin, cholecystokinin, peptide YY, oxyntomodulin, glucagon-like peptide-1 are reviewed in this article, emphasising both their effects on regulating satiety, physiological roles many systems. The dysfunctions anorexigenic peptides those processes will result metabolic disorders such as obesity type 2 diabetes. purpose review is also to consider important nesfatin-1, amylin obesity-related pathophysiological conditions. Key Concepts: Satiety satisfied feeling being full after eating. It refers inhibition eating following a meal. Neuropeptides play major role feeding CRF, melanocortins, BDNF, CART, nesfatin-1. Anorexigenic tract food intake CCK, OXM GLP-1. Obesity contributor cardiovascular disease, (type 1 or diabetes) various cancers. Obesity predisposes humans some chronic diseases diabetes, diseases, cancers it shortens life duration increases mortality rates. Understanding pathological health disease allow us find potential therapeutic targets for treatment disorders. Keywords: Satiety; leptin; CRF; melanocortins; BDNF; CART; NPB; NPW; nesfatin-1; obestatin; pancreatic polypeptide; amylin; CCK; peptide YY; OXM; GLP-1; obesity; type diabetes