Peripheral administration of D-cycloserine rescues memory consolidation following bacterial endotoxin exposure.
作者： Dinko Kranjac , Kyle M. Koster , Marielle S. Kahn , Micah J. Eimerbrink , Brent M. Womble
DOI: 10.1016/J.BBR.2012.12.053
关键词: NMDA receptor 、 Cycloserine 、 Immunology 、 Memory consolidation 、 D-cycloserine 、 Hippocampal formation 、 Agonist 、 Systemic administration 、 Lipopolysaccharide 、 Medicine
摘要: Abstract In the current study, partial NMDA receptor agonist d -cycloserine (DCS) rescued memory consolidation following systemic bacterial endotoxin exposure. DCS failed, however, to restore hippocampal BDNF mRNA levels that were diminished a administration of LPS, and did not alter NR1 or NR2C subunit expression. These results extend prior research into role in neural-immune interactions, indicate detrimental effects peripheral LPS on contextual fear may be ameliorated with treatment, though mechanisms underlying these are currently unclear.
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