Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene
作者： Brian P. Brunk , Elisabeth C. Martin , Paul N. Adler
DOI: 10.1038/353351A0
关键词: Gene product 、 Posterior Sex Combs 、 Antennapedia 、 Sequence alignment 、 Gene 、 Biology 、 Polyhomeotic 、 Homology (biology) 、 Homeotic selector gene 、 Genetics
摘要: THE Polycomb group (Pc-G) genes are needed to maintain expression patterns of the homeotic selector Antennapedia (Antp-C) and bithorax (bx-C) complexes, hence for maintenance segmental determination1–3. We report predicted protein sequence Pc-G gene Posterior Sex Combs (Psc), neighbouring related Suppressor two zeste (Su(z)2). Both encode large proteins that contain a 200 amino-acid domain identical over 37.4% is also conserved in murine oncogene bmi-1 (refs 4,5). At amino terminus this cysteine-rich has been proposed as novel type zinc finger6.
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G. Struhl, M. Akam, Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of Drosophila. The EMBO Journal. ,vol. 4, pp. 3259- 3264 ,(1985) , 10.1002/J.1460-2075.1985.TB04075.X
P N Adler, E C Martin, B P Brunk, Molecular genetics of the Posterior sex combs/Suppressor 2 of zeste region of Drosophila: aberrant expression of the Suppressor 2 of zeste gene results in abnormal bristle development. Genetics. ,vol. 128, pp. 119- 132 ,(1991) , 10.1093/GENETICS/128.1.119
M Takahashi, Y Inaguma, H Hiai, F Hirose, Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene. Molecular and Cellular Biology. ,vol. 8, pp. 1853- 1856 ,(1988) , 10.1128/MCB.8.4.1853
P N Adler, B P Brunk, Aristapedioid: A Gain of Function, Homeotic Mutation in Drosophila Melanogaster Genetics. ,vol. 124, pp. 145- 156 ,(1990) , 10.1093/GENETICS/124.1.145
B L Smiley, A W Stadnyk, P J Myler, K Stuart, The trypanosome leucine repeat gene in the variant surface glycoprotein expression site encodes a putative metal-binding domain and a region resembling protein-binding domains of yeast, Drosophila, and mammalian proteins. Molecular and Cellular Biology. ,vol. 10, pp. 6436- 6444 ,(1990) , 10.1128/MCB.10.12.6436
Paul S. Freemont, Isabel M. Hanson, John Trowsdale, A novel gysteine-rich sequence motif Cell. ,vol. 64, pp. 483- 484 ,(1991) , 10.1016/0092-8674(91)90229-R
Ygal Haupt, Warren S. Alexander, Gina Barri, S. Peter Klinken, Jerry M. Adams, Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice Cell. ,vol. 65, pp. 753- 763 ,(1991) , 10.1016/0092-8674(91)90383-A
Maarten van Lohuizen, Sjef Verbeek, Blanca Scheljen, Ellen Wientjens, Hanneke van der Guidon, Anton Berns, Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging Cell. ,vol. 65, pp. 737- 752 ,(1991) , 10.1016/0092-8674(91)90382-9
R. Patarca, G. J. Freeman, J. Schwartz, R. P. Singh, Q. T. Kong, E. Murphy, Y. Anderson, F. Y. Sheng, P. Singh, K. A. Johnson, rpt-1, an intracellular protein from helper/inducer T cells that regulates gene expression of interleukin 2 receptor and human immunodeficiency virus type 1. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 85, pp. 2733- 2737 ,(1988) , 10.1073/PNAS.85.8.2733
Edgar Serfling, Autoregulation - a common property of eukaryotic transcription factors? Trends in Genetics. ,vol. 5, pp. 131- 133 ,(1989) , 10.1016/0168-9525(89)90049-8