Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene.

摘要: The authors isolated and sequenced a cDNA clone of the human gene encoded by 5' half ret transforming gene. nucleotide sequence indicates that it encodes protein with ''finger'' structures which represent putative metal- nucleic acid-binding domains. Transcriptions this was detected at high levels in variety rodent tumor cell lines, mouse testis, embryos. In addition, unique transcript observed testis RNA. When expression examined different stages spermatogenesis, striking increase mRNA accompanied progression from meiotic prophase pachytene spermatocytes to postmeiotic round spermatids. This finger-containing may thus function male germ development.