RET/ptc and TRK Oncogenes in Papillary Thyroid Carcinoma

摘要: From the evidence that oncogenes of tumor viruses could be routinely detected by their ability to induce neoplastic transformation cells in culture, there arose possibility might also contain transforming genes detectable same way. Gene transfer techniques (transfection) were therefore used test DNA for presence that, when introduces into can elicit a transformed phenotype and form tumors animals (tumorigenicity). The first successful application this concept was obtained with mouse fibroblasts chemical carcinogen (Shih et al., 1979), but then applied number cell lines specimens (Weinberg, 1982; Varmus, 1984; Barbacid, 1987). A activity approximately 20% all tested some types rarely, or ever, containing transfection others displaying consistent frequencies activation one more oncogenes. great majority human cancers belongs family RAS proto-oncogenes (Barbacid,