Adenomatous Polyposis Coli
作者： I.M. Frayling , M.J. Arends
DOI: 10.1016/B978-0-12-374984-0.00016-4
关键词: Cytoskeletal Organization 、 Biology 、 Cell polarity 、 Pathology 、 Gene 、 Cancer research 、 Dysplasia 、 Cadherin 、 Adenoma 、 Adenomatous polyposis coli 、 Multipolar spindles
摘要: Adenomatous polyposis coli (APC) protein is the product of APC gene, located near 5q21–22 boundary. It involved in a number critical cellular processes such as cell polarity and cell–cell adhesion (with, e.g., E-cadherin β-catenin), cytoskeletal organization spindle formation, plus indirectly, β-catenin nuclear signaling. Inherited mutations gene are associated with development hundreds to thousands adenomatous polyps (i.e., benign tumors characterized by dysplasia) predominantly large bowel, predisposing cancers, well several extracolonic features.
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