The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.
作者： Hanan Lamlum , Mohammad Ilyas , Andrew Rowan , Susan Clark , Victoria Johnson
DOI: 10.1038/12511
关键词:
摘要: APC is often cited as a prime example of a tumor suppressor gene. Truncating germline and somatic mutations (or, infrequently, allelic loss) occur in tumors in FAP (familial …
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