Selection, the mutation rate and cancer: Ensuring that the tail does not wag the dog
作者： Ian Tomlinson , Walter Bodmer
DOI: 10.1038/4687
关键词:
摘要: In considering tumorigenesis, much attention is paid to genome instability and mutation rates. While reflecting on the circumstances that have led this emphasis rates, Ian Tomlinson Walter Bodmer point out an increased rate does not necessarily cause a tumor grow selection in fact mechanism drives cellular, somatic evolution leads cancer.
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