An Experimental Model of Autoimmune Pancreatitis in the Rat

摘要: Autoimmune pancreatitis (AIP), a recently defined disease of unknown etiology, is characterized by inflammatory infiltrates in the pancreas with conspicuous involvement ducts. The clinically manifests humans as epigastric pain, weight loss, and jaundice. This report describes development novel animal model this rat, which we have termed experimental autoimmune pancreatitis. Adoptive transfer amylase-specific CD4 + T cells was able to confer naive syngeneic recipient animals. No treatments before adoptive were necessary for ensue, severity proportional number administered. pancreatic lesions rats histologically overwhelmingly lymphocytic occasional plasma cells, neutrophils, mast cells. Acinar tissue destruction ductular inflammation common features, less frequent larger Immunohistochemical analysis revealed presence large numbers well CD8 macrophages, dendritic Expression MHC I II also increased at site lesion. Clinically, manifested either failure gain rate concomitant control animals or outright loss. Thus, administration activated specific enzyme amylase can induce rat manner that reminiscent human AIP.