The Wistar Bonn Kobori rat, a unique animal model for autoimmune pancreatitis with extrapancreatic exocrinopathy.
作者： Y. Sakaguchi , M. Inaba , M. Tsuda , G. K. Quan , M. Omae
DOI: 10.1111/J.1365-2249.2008.03588.X
关键词:
摘要: Summary The male Wistar Bonn/Kobori (WBN/Kob) rat is known to be a unique animal model for chronic pancreatitis with widely distributed fibrosis and degeneration of parenchyma because the infiltration lymphocytes. In this report,we show that female (but not male) rats develop dacryoadenitis at 3 months age, both WBN/Kob sialoadenitis, thyroiditis, sclerotic cholangitis tubulointerstitial nephritis over 18 age. CD8 + cells deposits tissue-specific IgG2b were observed in injured pancreas lachrymal glands. Furthermore, number regulatory T (defined as CD4 Forkhead box P3 cells) decreased periphery rats, suggesting onset these diseases attribut- able, least, failure maintenance peripheral immune tolerance. These features clearly are useful autoimmune Sjogren-like syndrome or multi-focal fibrosclerosisinhumans.Wealsoshowthattheseautoimmunediseasescanbe preventedbyanewlydevisedstrategyof bonemarrowtransplantation(BMT) which bone marrow injected directly into cavity: intrabone marrow-BMT.
sci-hub.se 参考文章(44)
Terumi Kamisawa, Involvement of pancreatic and bile ducts in autoimmune pancreatitis World Journal of Gastroenterology. ,vol. 12, pp. 612- 614 ,(2006) , 10.3748/WJG.V12.I4.612
Kazuo Tsubota, Kazuo Tsubota, Kensei Tsuzaka, Tsutomu Takeuchi, Hiromi Fujita, Mikulicz's disease and Sjögren's syndrome. Investigative Ophthalmology & Visual Science. ,vol. 41, pp. 1666- 1673 ,(2000)
Todd S. Davidson, Daniel S. Longnecker, William F. Hickey, An Experimental Model of Autoimmune Pancreatitis in the Rat American Journal of Pathology. ,vol. 166, pp. 729- 736 ,(2005) , 10.1016/S0002-9440(10)62294-8
Takashi Hashimoto, Tamaki Yamada, Takio Yokoi, Hitoshi Sano, Hakuji Ando, Takahiro Nakazawa, Hirotaka Ohara, Tomoyuki Nomura, Takashi Joh, Makoto Itoh, Apoptosis of acinar cells is involved in chronic pancreatitis in Wbn/Kob rats: role of glucocorticoids. Pancreas. ,vol. 21, pp. 296- 304 ,(2000) , 10.1097/00006676-200010000-00012
SIMON SKURKOVICH, BORIS SKURKOVICH, Anticytokine Therapy, Especially Anti‐Interferon‐γ, as a Pathogenetic Treatment in TH‐1 Autoimmune Diseases Annals of the New York Academy of Sciences. ,vol. 1051, pp. 684- 700 ,(2005) , 10.1196/ANNALS.1361.113
Babak Etemad, David C. Whitcomb, Chronic pancreatitis: Diagnosis, classification, and new genetic developments Gastroenterology. ,vol. 120, pp. 682- 707 ,(2001) , 10.1053/GAST.2001.22586
S Ikehara, Treatment of autoimmune diseases by hematopoietic stem cell transplantation Experimental Hematology. ,vol. 29, pp. 661- 669 ,(2001) , 10.1016/S0301-472X(01)00645-2
S. Ikehara, R. A. Good, T. Nakamura, K. Sekita, S. Inoue, M. M. Oo, E. Muso, K. Ogawa, Y. Hamashima, Rationale for bone marrow transplantation in the treatment of autoimmune diseases. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 2483- 2487 ,(1985) , 10.1073/PNAS.82.8.2483
Kenji Kawaguchi, Morio Koike, Koji Tsuruta, Atsutake Okamoto, Ikuo Tabata, Naotaka Fujita, Lymphoplasmacytic sclerosing pancreatitis with cholangitis: A variant of primary sclerosing cholangitis extensively involving pancreas Human Pathology. ,vol. 22, pp. 387- 395 ,(1991) , 10.1016/0046-8177(91)90087-6
H. KANNO, M. NOSE, J. ITOH, Y. TANIGUCHI, M. KYOGOKU, Spontaneous development of pancreatitis in the MRL/Mp strain of mice in autoimmune mechanism Clinical and Experimental Immunology. ,vol. 89, pp. 68- 73 ,(2008) , 10.1111/J.1365-2249.1992.TB06879.X