Possible Involvement of Foxp3+ Regulatory T Cells in the Development of Immune-Mediated Pancreatitis in MRL/Mp Mice Treated with Polyinosinic:Polycytidylic Acid
作者： Masanori Koyabu , Kazushige Uchida , Yutaku Sakaguchi , Norimasa Fukata , Takeo Kusuda
DOI: 10.1155/2013/367325
关键词:
摘要: Objectives. This study was conducted to clarify whether or not Tregs are involved in the development of immune-mediated pancreatitis MRL/Mp mice as an AIP (autoimmune pancreatitis) model, order understand more clearly pathogenic mechanism AIP. Methods. We compared immunohistochemical features pancreatic forkhead box P3 (Foxp3) administration poly I:C and two types control (BALB/c C57BL/6). As a contrast, we analyzed three mouse models without autoimmune (Cerulein-, Ligation-, Ligation + Cerulein-treated mice). After staining these specimens, ratios Foxp3-positive cells infiltrated mononuclear (Foxp3/Mono). Results. Our Foxp3 revealed that infiltration increased I:C-treated mice. The histopathological score showed no difference among MRL/Mp, mice; however, Foxp3/Mono ratio significantly with Ligation- Conclusions. treated early abundant cells. There may be possibility
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