Recognition and plasma clearance of endotoxin by scavenger receptors.

摘要: Lipid A is the active moiety of lipopolysaccharide (LPS, also referred to as endotoxin), a surface component Gram-negative bacteria that stimulates macrophage activation and causes endotoxic shock. Macrophages can bind, internalize partially degrade LPS, lipid its bioactive precursor, IVA. We report here IVA binding subsequent metabolism less form by macrophage-like RAW 264.7 cells mediated scavenger receptor. Scavenger-receptor ligands inhibit to, by, cells, binds type I II bovine receptors on transfected Chinese hamster ovary cells. Although in vitro competition studies with indicate receptor not involved LPS or IVA-induced stimulation macrophages, vivo show scavenger-receptor greatly hepatic uptake mice. Thus, expressed macrophages may have an important role clearance detoxification endotoxin animals.