Pattern Recognition Receptors in Drosophila
作者： Mika Rämet , Asha Harikrishnan , Kati Baksa , Alan Pearson
DOI: 10.1007/978-1-59259-320-0_7
关键词:
摘要: The foundation of the innate immune system is recognition infectious non-self. Janeway (1,2) has proposed that this mediated by binding host pattern proteins to pathogen-associated molecular patterns (PAMPs). PAMPs were originally defined as structures found on surfaces microorganisms but not present normal cells. More recently, definition been broadened include intracellular components microorganisms, such CpG DNA (3). There are several different classes including secreted, membrane-bound, and integral membrane proteins, some molecules can exist in more than one these forms. Recognition consequences, activation induced cellular humoral responses, induction antimicrobial genes Drosophila, T- cells mammals. Pattern also participate effector mechanisms system, complement (mammals) prophenoloxidase (insect) cascades, well phagocytosis microorganisms.
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