A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation.

摘要: Background Acute intervertebral disk herniation (IVDH) is a common cause of spinal cord injury in dogs and currently there no proven medical treatment to counter secondary effects. Use methylprednisolone sodium succinate (MPSS) or polyethylene glycol (PEG) as neuroprotectants advocated but controversial because neither has been tested placebo-controlled, randomized, blinded trials dogs. Hypothesis Polyethylene will improve the outcome severe caused by IVDH compared MPSS placebo. Animals Client-owned with acute onset thoracolumbar causing paralysis loss nociception for <24 hours. Methods Dogs were randomized receive MPSS, PEG, placebo; drugs appeared identical group allocation was masked. Drug administration initiated once diagnosis confirmed all underwent hemilaminectomy. Neurologic function assessed 2, 4, 8, 12 weeks postoperatively using an open field gait score (OFS) primary measure. Outcomes Wilcoxon rank sum test. Results Sixty-three recruited 47.6% recovered ambulation. 17.5% developed progressive myelomalacia association group. There difference OFS among groups. Although full study power not reached, conditional analyses indicated futility continued case recruitment. Conclusions This clinical trial did show benefit either PEG acute, when used adjunctive administered presenting within 24 hours paralysis.