Neuropathology of the 21th century for the Latin American epilepsy community.

摘要: Abstract Many people with epilepsy remain drug-resistant, despite continuous efforts and advances in research treatment. It is mandatory to understand the epilepsy’s underlying etiology, whether it structural, genetic, infectious, metabolic, immune or (currently) unknown, as contains major information about clinical phenotype, cognitive comorbidities, (new) drug targets also help predict postsurgical outcome. A multimodal approach, including digital slides multichannel immunofluorescence labelling can increase diagnostic yield of subtle pathologies, while DNA methylation arrays could helps diagnosis difficult-to-classify lesions. Such techniques are not always available, however, low-income countries. Even without access expensive molecular techniques, automated analysis scripts machine learning algorithms be developed by Latin American researchers improve our from routine Hematoxylin & Eosin stained tissue sections. The pathology community America contributed substantially current knowledge etiologies related human epilepsies experimental models. To further boost impact research, local centers should adhere modern, neuropathology integrate different levels knowledge, strengthen their scientific collaborations. Dedicated teaching courses Epileptology, such Summer Schools Epilepsy (LASSE) International School for Neuropathology Surgery (INES) addressing young researcher neurologists, most successful promote this endeavor. In review, we will describe state at 21st century highlight researchers' contributions epilepsy.