Bone marrow necrosis
作者： Ann M. Janssens , Fritz C. Offner , Werner Z. Van Hove
DOI: 10.1002/(SICI)1097-0142(20000415)88:8<1769::AID-CNCR3>3.0.CO;2-H
关键词: Bone marrow 、 Gastroenterology 、 Medicine 、 Etiology 、 Bone pain 、 Pathology 、 Anemia 、 Leukemia 、 Internal medicine 、 Cancer 、 Pancytopenia 、 Malignancy
摘要: BACKGROUND In the medical community, little is known regarding bone marrow necrosis (BMN) as a clinicopathologic entity, although to authors' knowledge it was described for first time more than 50 years ago. To identify rate of prevalence, symptoms and signs, underlying disease associations, usefulness diagnostic procedures, an extensive literature search made. METHODS Only cases identified diagnosed during life were selected. Two hundred forty met these criteria. RESULTS Bone pain (75%) fever (68.5%) most important symptoms, whereas anemia (91%) thrombocytopenia (78%), associated with leukoerythroblastic picture (51%), frequent hematologic abnormalities. Nearly 50% patients showed elevated lactate dehydrogenase alkaline phosphatase levels. In 90% malignancy identified. CONCLUSIONS Bone caused by hypoxemia after failure microcirculation. Given high association, neoplastic justified whenever BMN diagnosed. Pancytopenia embolic processes are major complications that should be managed supportive measures until effective treatment has been administered. When resolves, repopulation cavity normal hematopoiesis observed. Cancer 2000;88:1769–80. © 2000 American Society.
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